Molecular weight (DA)
101kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CHD1L. AA range:545-594
Specificity
CHD1L Polyclonal Antibody detects endogenous levels of CHD1L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
chromodomain helicase DNA binding protein 1 like(CHD1L) Homo sapiens This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012],
Function
function:Putative DNA helicase, which may play a role in chromatin-remodeling. In vitro, promotes cell proliferation and inhibits apoptois.,similarity:Belongs to the SNF2/RAD54 helicase family.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,similarity:Contains 1 Macro domain.,tissue specificity:Frequently overexpresssed in hepatomacellular carcinomas.,
Protein name
Chromodomain-helicase-DNA-binding protein 1-like
Other name
CHD1L; ALC1; Chromodomain-helicase-DNA-binding protein 1-like; Amplified in liver cancer protein 1
Human protein sequence Database
Q86WJ1
Mouse protein sequence database
Q9CXF7
Rat protein sequence database
Cellular localization
Nucleus . Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1. .
Tissue expression
Frequently overexpressed in hepatomacellular carcinomas.
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