Molecular weight (DA)
61kD
Immunogen
Synthesized peptide derived from the Internal region of human ZKSCAN4.
Specificity
ZKSCAN4 Polyclonal Antibody detects endogenous levels of ZKSCAN4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:May be involved in the transcriptional activation of MDM2 and EP300 genes.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 KRAB domain.,similarity:Contains 1 SCAN box domain.,similarity:Contains 7 C2H2-type zinc fingers.,tissue specificity:Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.,
Function
function:May be involved in the transcriptional activation of MDM2 and EP300 genes.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 KRAB domain.,similarity:Contains 1 SCAN box domain.,similarity:Contains 7 C2H2-type zinc fingers.,tissue specificity:Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.,
Protein name
Zinc finger protein with KRAB and SCAN domains 4
Other name
ZKSCAN4; ZNF307; ZNF427; Zinc finger protein with KRAB and SCAN domains 4; P373c6.1; Zinc finger protein 307; Zinc finger protein 427
Human protein sequence Database
Q969J2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in adult heart, brain, placenta, lung and kidney, but not in adult liver and skeletal muscle. In 17-day old embryo, detected in liver, skeletal muscle, brain, heart and small intestine.
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