Molecular weight (DA)
15 37kD
Immunogen
Synthesized peptide derived from human CATB (Cleaved-Asn126)
Specificity
This antibody detects endogenous levels of Human CATB (Cleaved-Asn126, protein was cleaved amino acid sequence between 126-127 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,
Function
proteolysis, response to wounding, regulation of cell death, regulation of apoptosis, regulation of programmed cell death,
Protein name
CATB (Cleaved-Asn126)
Other name
Cathepsin B (EC 3.4.22.1;APP secretase;APPS;Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
Fields
>>Autophagy - animal;>>Lysosome;>>Apoptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>Renin secretion
Human protein sequence Database
P07858
Mouse protein sequence database
P10605
Rat protein sequence database
P00787
Cellular localization
Lysosome . Melanosome . Secreted, extracellular space . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). .
Tissue expression
Expressed in the stratum spinosum of the epidermis. Weak expression is detected in the stratum granulosum.
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