Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ABHD7. AA range:101-150
Specificity
ABHD7 Polyclonal Antibody detects endogenous levels of ABHD7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The α/β hydrolase superfamily comprise diverse members that are involved in important biochemical processes and related to various diseases. They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical α/β hydrolase fold, which consists of an eight-stranded parallel α/β structure. They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile. Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer's disease, obesity and blood clotting disorders. The Ab hydrolase domain containing (ABHD) gene subfamily is comprised of 15 mostly uncharacterized members, most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow. ABHD7 is a 362 amino acid single-pass type II membrane protein that belongs to the AB hydrolase superfamily and the Epoxide hydrolase family.
Protein name
Epoxide hydrolase 4
Other name
EPHX4; ABHD7; EPHXRP; Epoxide hydrolase 4; Abhydrolase domain-containing protein 7; Epoxide hydrolase-related protein
Fields
>>Chemical carcinogenesis - receptor activation;>>Chemical carcinogenesis - reactive oxygen species
Human protein sequence Database
Q8IUS5
Mouse protein sequence database
Q6IE26
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type II membrane protein .
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