Molecular weight (DA)
78kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ACSL6. AA range:499-548
Specificity
ACSL6 Polyclonal Antibody detects endogenous levels of ACSL6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011],
Function
catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.,cofactor:Magnesium.,developmental stage:Expression is low at earlier stages of erythroid development but is very high in reticulocytes.,disease:A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6.,disease:A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6.,disease:A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.,function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utiliz
Protein name
Long-chain-fatty-acid--CoA ligase 6
Other name
ACSL6; ACS2; FACL6; KIAA0837; LACS5; Long-chain-fatty-acid--CoA ligase 6; Long-chain acyl-CoA synthetase 6; LACS 6
Fields
>>Fatty acid biosynthesis;>>Fatty acid degradation;>>Metabolic pathways;>>Fatty acid metabolism;>>PPAR signaling pathway;>>Peroxisome;>>Ferroptosis;>>Thermogenesis;>>Adipocytokine signaling pathway
Human protein sequence Database
Q9UKU0
Mouse protein sequence database
Q91WC3
Rat protein sequence database
P33124
Cellular localization
Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein . Microsome membrane ; Single-pass type III membrane protein . Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
Tissue expression
Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
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