Molecular weight (DA)
37kD
Immunogen
Synthesized peptide derived from AKR1A1 . at AA range: 250-330
Specificity
AKR1A1 Polyclonal Antibody detects endogenous levels of AKR1A1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011],
Function
catalytic activity:An alcohol + NADP(+) = an aldehyde + NADPH.,function:Catalyzes the NADPH-dependent reduction of a variety of aldehydes to their corresponding alcohols.,similarity:Belongs to the aldo/keto reductase family.,subunit:Monomer.,
Protein name
Alcohol dehydrogenase [NADP(+)]
Other name
AKR1A1; ALDR1; ALR; Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1
Fields
>>Glycolysis / Gluconeogenesis;>>Pentose and glucuronate interconversions;>>Ascorbate and aldarate metabolism;>>Glycerolipid metabolism;>>Pyruvate metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Chemical carcinogenesis - reactive oxygen species
Human protein sequence Database
P14550
Mouse protein sequence database
Q9JII6
Rat protein sequence database
P51635
Cellular localization
Cytoplasm, cytosol . Apical cell membrane .
Tissue expression
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
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