Molecular weight (DA)
48kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cathepsin E. AA range:243-292
Specificity
Cathepsin E Polyclonal Antibody detects endogenous levels of Cathepsin E protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015],
Function
catalytic activity:Similar to cathepsin D, but slightly broader specificity.,function:May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.,PTM:Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.,PTM:Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.,similarity:Belongs to the peptidase A1 family.,subcellular location:The proenzyme is localized
Other name
CTSE; Cathepsin E
Human protein sequence Database
P14091
Mouse protein sequence database
P70269
Rat protein sequence database
P16228
Cellular localization
Endosome . The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Tissue expression
Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
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