Molecular weight (DA)
31kD
Immunogen
The antiserum was produced against synthesized peptide derived from human COX11. AA range:51-100
Specificity
COX11 Polyclonal Antibody detects endogenous levels of COX11 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to c
Function
function:Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.,similarity:Belongs to the COX11/ctaG family.,subunit:Interacts with CNNM4/ACDP4.,tissue specificity:Ubiquitous.,
Protein name
Cytochrome c oxidase assembly protein COX11 mitochondrial
Other name
COX11; Cytochrome c oxidase assembly protein COX11; mitochondrial
Fields
>>Oxidative phosphorylation;>>Metabolic pathways;>>Thermogenesis
Human protein sequence Database
Q9Y6N1
Mouse protein sequence database
Q6P8I6
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side .
Tissue expression
Ubiquitous.
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