Molecular weight (DA)
67kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CTPS. AA range:60-109
Specificity
CTPS Polyclonal Antibody detects endogenous levels of CTPS protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function
catalytic activity:ATP + UTP + NH(3) = ADP + phosphate + CTP.,enzyme regulation:Activated by GTP and inhibited by CTP.,function:Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.,pathway:Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.,similarity:Belongs to the CTP synthase family.,similarity:Contains 1 glutamine amidotransferase type-1 domain.,
Protein name
CTP synthase 1
Other name
CTPS1; CTPS; CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1
Fields
>>Pyrimidine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors
Human protein sequence Database
P17812
Mouse protein sequence database
P70698
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol . Mainly cytosolic but when active detected in long filamentous structures (PubMed:25223282). Co-localizes with TNK2 in the cytosolic filaments (By similarity). .
Tissue expression
Widely expressed.
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