Immunogen
The antiserum was produced against synthesized peptide derived from human CYP26C1. AA range:41-90
Specificity
CYP26C1 Polyclonal Antibody detects endogenous levels of CYP26C1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cytochrome P450 family 26 subfamily C member 1(CYP26C1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008],
Function
cofactor:Heme group.,function:Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).,induction:By retinoic acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Detected in most tissues at very low level.,
Protein name
Cytochrome P450 26C1
Other name
CYP26C1; Cytochrome P450 26C1
Fields
>>Retinol metabolism;>>Metabolic pathways
Human protein sequence Database
Q6V0L0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Single-pass membrane protein .
Tissue expression
Detected in most tissues at very low level.
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