Molecular weight (DA)
61kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2U1. AA range:281-330
Specificity
CYP2U1 Polyclonal Antibody detects endogenous levels of CYP2U1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008],
Function
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,developmental stage:Expressed in fetal thymus.,function:Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Widely expressed with stronger expression in thymus, heart and cerebellum.,
Protein name
Cytochrome P450 2U1
Other name
CYP2U1; Cytochrome P450 2U1
Fields
>>Fatty acid degradation;>>Arachidonic acid metabolism;>>Metabolic pathways
Human protein sequence Database
Q7Z449
Mouse protein sequence database
Q9CX98
Rat protein sequence database
Q4V8D1
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein . Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed with stronger expression in thymus, heart and cerebellum.
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