Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GGH. AA range:251-300
Specificity
GGH Polyclonal Antibody detects endogenous levels of GGH protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Hydrolysis of a gamma-glutamyl bond.,function:Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.,similarity:Belongs to the peptidase C26 family.,similarity:Contains 1 gamma-glutamyl hydrolase domain.,subcellular location:While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
Protein name
Gamma-glutamyl hydrolase
Other name
GGH; Gamma-glutamyl hydrolase; Conjugase; GH; Gamma-Glu-X carboxypeptidase
Fields
>>Folate biosynthesis;>>Biosynthesis of cofactors;>>Antifolate resistance
Human protein sequence Database
Q92820
Mouse protein sequence database
Q9Z0L8
Rat protein sequence database
Cellular localization
Secreted, extracellular space . Lysosome . Melanosome . While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
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