Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human B4GALNT1. AA range:281-330
Specificity
GM2/GD2 synthase Polyclonal Antibody detects endogenous levels of GM2/GD2 synthase protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
beta-1,4-N-acetyl-galactosaminyltransferase 1(B4GALNT1) Homo sapiens GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013],
Function
catalytic activity:UDP-N-acetyl-D-galactosamine + 1-O-(O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide = UDP + 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-(N-acetyl-alpha-neuraminosyl-(2->3))-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl)-ceramide.,function:Involved in the biosynthesis of gangliosides GM2, GD2 and GA2.,online information:Beta-1,4 N-acetylgalactosaminyltransferase 1,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 2 family.,subunit:Homodimer; disulfide-linked.,
Protein name
Beta-1,4 N-acetylgalactosaminyltransferase 1
Abbreviation
GM2/GD2 synthase
Other name
B4GALNT1; GALGT; SIAT2; Beta-1; 4 N-acetylgalactosaminyltransferase 1; (N-acetylneuraminyl)-galactosylglucosylceramide; GM2/GD2 synthase; GalNAc-T
Fields
>>Sphingolipid metabolism;>>Glycosphingolipid biosynthesis - ganglio series;>>Metabolic pathways
Human protein sequence Database
Q00973
Mouse protein sequence database
Q09200
Rat protein sequence database
Q10468
Cellular localization
Golgi apparatus membrane ; Single-pass type II membrane protein .
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