Molecular weight (DA)
46kD
Immunogen
The antiserum was produced against synthesized peptide derived from human LASS4. AA range:41-90
Specificity
LASS4 Polyclonal Antibody detects endogenous levels of LASS4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,
Function
function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donnors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,
Protein name
Ceramide synthase 4
Other name
CERS4; LASS4; Ceramide synthase 4; CerS4; LAG1 longevity assurance homolog 4
Fields
>>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway
Human protein sequence Database
Q9HA82
Mouse protein sequence database
Q9D6J1
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Cerebellum,Embryo,Lung,
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