Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PSMD6. AA range:201-250
Specificity
p44S10 Polyclonal Antibody detects endogenous levels of p44S10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012],
Function
function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit S10 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex.,
Protein name
26S proteasome non-ATPase regulatory subunit 6
Other name
PSMD6; KIAA0107; PFAAP4; 26S proteasome non-ATPase regulatory subunit 6; 26S proteasome regulatory subunit RPN7; 26S proteasome regulatory subunit S10; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4;
Fields
>>Proteasome;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Epstein-Barr virus infection
Human protein sequence Database
Q15008
Mouse protein sequence database
Q99JI4
Rat protein sequence database
Cellular localization
proteasome complex,nucleoplasm,cytosol,proteasome regulatory particle,proteasome accessory complex,extracellular exosome,
Tissue expression
Bone marrow,Lymph,Mammary cancer,Ovary,Placenta,Testis,
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