Molecular weight (DA)
86kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SENP5. AA range:651-700
Specificity
SENP5 Polyclonal Antibody detects endogenous levels of SENP5 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009],
Function
function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.,similarity:Belongs to the peptidase C48 family.,
Protein name
Sentrin-specific protease 5
Other name
SENP5; FKSG45; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5
Human protein sequence Database
Q96HI0
Mouse protein sequence database
Q6NXL6
Rat protein sequence database
Cellular localization
Nucleus, nucleolus .
Tissue expression
Placenta,Testis,
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