Molecular weight (DA)
27kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SENP8. AA range:161-210
Specificity
SENP8 Polyclonal Antibody detects endogenous levels of SENP8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009],
Function
function:Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53.,similarity:Belongs to the peptidase C48 family.,tissue specificity:Broadly expressed, with highest levels in kidney and pancreas.,
Protein name
Sentrin-specific protease 8
Other name
SENP8; DEN1; NEDP1; PRSC2; FKSG8; Sentrin-specific protease 8; Deneddylase-1; NEDD8-specific protease 1; Protease; cysteine 2; Sentrin/SUMO-specific protease SENP8
Human protein sequence Database
Q96LD8
Mouse protein sequence database
Q9D2Z4
Rat protein sequence database
Q5FVJ8
Tissue expression
Broadly expressed, with highest levels in kidney and pancreas.
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