Molecular weight (DA)
140kD
Immunogen
The antiserum was produced against synthesized peptide derived from human USP40. AA range:1011-1060
Specificity
USP40 Polyclonal Antibody detects endogenous levels of USP40 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008],
Function
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:May be catalytically inactive.,similarity:Belongs to the peptidase C19 family.,tissue specificity:Broadly expressed.,
Protein name
Ubiquitin carboxyl-terminal hydrolase 40
Other name
USP40; Ubiquitin carboxyl-terminal hydrolase 40; Deubiquitinating enzyme 40; Ubiquitin thioesterase 40; Ubiquitin-specific-processing protease 40
Human protein sequence Database
Q9NVE5
Mouse protein sequence database
Q8BWR4
Rat protein sequence database
Cellular localization
nucleus,cytoplasm,
Tissue expression
Broadly expressed.
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