Molecular weight (DA)
39kD
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALDOC. AA range:21-70
Specificity
Aldolase C Polyclonal Antibody detects endogenous levels of Aldolase C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008],
Function
catalytic activity:D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.,miscellaneous:In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.,pathway:Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.,similarity:Belongs to the class I fructose-bisphosphate aldolase family.,subunit:Homotetramer.,
Protein name
Fructose-bisphosphate aldolase C
Other name
ALDOC; ALDC; Fructose-bisphosphate aldolase C; Brain-type aldolase
Fields
>>Glycolysis / Gluconeogenesis;>>Pentose phosphate pathway;>>Fructose and mannose metabolism;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>HIF-1 signaling pathway
Human protein sequence Database
P09972
Mouse protein sequence database
P05063
Rat protein sequence database
P09117
Cellular localization
mitochondrion,cytosol,cytoskeleton,extracellular exosome,
Tissue expression
Brain,Colon,Epithelium,Eye,Uterus,
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