Molecular weight (DA)
72kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human HDC. AA range:201-250
Specificity
HDC Polyclonal Antibody detects endogenous levels of HDC protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010],
Function
catalytic activity:L-histidine = histamine + CO(2).,cofactor:Pyridoxal phosphate.,pathway:Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.,similarity:Belongs to the group II decarboxylase family.,subunit:Homodimer.,
Protein name
Histidine decarboxylase
Other name
HDC; Histidine decarboxylase; HDC
Fields
>>Histidine metabolism;>>Metabolic pathways
Human protein sequence Database
P19113
Mouse protein sequence database
P23738
Rat protein sequence database
P16453
Cellular localization
cytosol,
Tissue expression
Leukemia,
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