Molecular weight (DA)
56kD
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALDH2. AA range:41-90
Specificity
ALDH2 Polyclonal Antibody detects endogenous levels of ALDH2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform,
Function
catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,disease:Defects in ALDH2 are a cause of acute alcohol sensitivity [MIM:610251]. There are wide individual differences in responses to drinking alcohol. Recent estimates claim that subjective effects (how people feel when they drink) vary from 200%-300% in the adult population, and ethanol metabolism (how quickly alcohol is absorbed into the bloodstream and metabolized by the liver) varies by approximately 200%. Unfortunately, alcohol researchers know very little about why such drastic differences occur between individuals and how individual differences in alcohol sensitivity might link drinking behavior with problematic alcohol-related outcomes.,pathway:Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.,polymorphism:Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication
Protein name
Aldehyde dehydrogenase mitochondrial
Other name
ALDH2; ALDM; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI
Fields
>>Glycolysis / Gluconeogenesis;>>Ascorbate and aldarate metabolism;>>Fatty acid degradation;>>Valine, leucine and isoleucine degradation;>>Lysine degradation;>>Arginine and proline metabolism;>>Histidine metabolism;>>Tryptophan metabolism;>>beta-Alanine metabolism;>>Glycerolipid metabolism;>>Pyruvate metabolism;>>Pantothenate and CoA biosynthesis;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Alcoholic liver disease
Human protein sequence Database
P05091
Mouse protein sequence database
P47738
Rat protein sequence database
P11884
Cellular localization
Mitochondrion matrix.
Tissue expression
Adipocyte,Brain,Cajal-Retzius cell,Liver,Lymph,Muscle,Small
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