Immunogen
Purified recombinant fragment of human TCP-1 β expressed in E. Coli.
Specificity
TCP-1 β Monoclonal Antibody detects endogenous levels of TCP-1 β protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
Function
function:Molecular chaperone; assist the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.,similarity:Belongs to the TCP-1 chaperonin family.,subunit:Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.,
Protein name
T-complex protein 1 subunit beta
Other name
CCT2; 99D8.1; CCTB; T-complex protein 1 subunit beta; TCP-1-beta; CCT-beta
Human protein sequence Database
P78371
Mouse protein sequence database
P80314
Rat protein sequence database
Q5XIM9
Cellular localization
Cytoplasm .
Tissue expression
B-cell lymphoma,Brain,Cajal-Retzius cell,Fetal brain cortex,Liver,P
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