Molecular weight (DA)
76kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TUBGCP4. AA range:191-240
Specificity
GCP4 Polyclonal Antibody detects endogenous levels of GCP4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015],
Function
function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.,similarity:Belongs to the GCP family.,subunit:Gamma-tubulin complex is composed of gamma-tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6.,tissue specificity:Ubiquitously expressed.,
Protein name
Gamma-tubulin complex component 4
Other name
TUBGCP4; 76P; GCP4; Gamma-tubulin complex component 4; GCP-4; hGCP4; Gamma-ring complex protein 76 kDa; h76p; hGrip76
Human protein sequence Database
Q9UGJ1
Mouse protein sequence database
Q9D4F8
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Tissue expression
Ubiquitously expressed.
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