Molecular weight (DA)
53kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PPHLN. AA range:71-120
Specificity
Periphilin 1 Polyclonal Antibody detects endogenous levels of Periphilin 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Function
function:Involved in epithelial differentiation and contributes to epidermal integrity and barrier formation.,PTM:Substrate of transglutaminase (in vitro).,subcellular location:In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions.,subunit:Homodimer. Interacts with PPL.,tissue specificity:Ubiquitous.,
Protein name
Periphilin-1
Abbreviation
Periphilin 1
Other name
PPHLN1; HSPC206; HSPC232; Periphilin-1; Gastric cancer antigen Ga50
Human protein sequence Database
Q8NEY8
Mouse protein sequence database
Q8K2H1
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Chromosome . In undifferentiated keratinocytes expressed in speckle-type nuclear granules and at the nuclear membrane, but in the differentiated keratinocytes colocalized with periplakin at the cell periphery and at cell-cell junctions (PubMed:12853457). Localizes to chromatin (PubMed:26022416). .
Tissue expression
Ubiquitous.
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