Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human COT2. AA range:1-50
Specificity
ARP-1 Polyclonal Antibody detects endogenous levels of ARP-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Function
function:Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with SQSTM1 (By similarity). Binds DNA as a homodimer.,tissue specificity:Found in all tissues.,
Protein name
COUP transcription factor 2
Other name
NR2F2; ARP1; TFCOUP2; COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2
Human protein sequence Database
P24468
Mouse protein sequence database
P43135
Rat protein sequence database
O09018
Cellular localization
Nucleus.
Tissue expression
Ubiquitous. Expressed in the stromal cells of developing fetal ovaries (PubMed:29478779).
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