Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NR4A3. AA range:387-436
Specificity
NOR-1 Polyclonal Antibody detects endogenous levels of NOR-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],
Function
disease:A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N.,disease:A chromosomal aberration involving NR4A3 is a cause of Ewing sarcoma [MIM:133450]. Translocation t(9;22)(q22-31;q11-12) with EWS.,function:Binds to the B1A response-element.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,tissue specificity:High expression of isoform alpha in skeletal muscle. High expression of isoform beta in skeletal muscle and low expression in fetal brain and placenta.,
Protein name
Nuclear receptor subfamily 4 group A member 3
Other name
NR4A3; CHN; CSMF; MINOR; NOR1; TEC; Nuclear receptor subfamily 4 group A member 3; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
Q92570
Mouse protein sequence database
Q9QZB6
Rat protein sequence database
P51179
Cellular localization
Nucleus .
Tissue expression
Isoform alpha is highly expressed in skeletal muscle. Isoform beta is highly expressed in skeletal muscle and low expressed in fetal brain and placenta.
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