Immunogen
Purified recombinant fragment of human Dkk-3 expressed in E. Coli.
Specificity
Dkk-3 Monoclonal Antibody detects endogenous levels of Dkk-3 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
Function
function:Inhibitor of Wnt signaling pathway .,PTM:N-glycosylated.,similarity:Belongs to the dickkopf family.,tissue specificity:Highest expression in heart, brain, and spinal cord.,
Protein name
Dickkopf-related protein 3
Other name
DKK3; REIC; Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3
Human protein sequence Database
Q9UBP4
Mouse protein sequence database
Q9QUN9
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Highest expression in heart, brain, and spinal cord.
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