Immunogen
Purified recombinant fragment of human Fibrinogen γ expressed in E. Coli.
Specificity
Fibrinogen γ Monoclonal Antibody detects endogenous levels of Fibrinogen γ protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015],
Function
disease:Defects in FGG are a cause of congenital afibrinogenemia [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.,disease:Defects in FGG are a cause of thrombophilia.,domain:A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.,function:Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.,miscellaneous:The gamma-chain carries the main binding site for the platelet receptor.,online information:Fibrinogen entry,PTM:Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes th
Protein name
Fibrinogen gamma chain
Abbreviation
Fibrinogen γ
Other name
FGG; Fibrinogen gamma chain
Fields
>>Complement and coagulation cascades;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Staphylococcus aureus infection;>>Coronavirus disease - COVID-19
Human protein sequence Database
P02679
Mouse protein sequence database
Q8VCM7
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Detected in blood plasma (at protein level).
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