Immunogen
Purified recombinant fragment of Protein Z expressed in E. Coli.
Specificity
Protein Z Monoclonal Antibody detects endogenous levels of Protein Z protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012],
Function
caution:Although homologous with the vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues and has no enzymatic activity.,function:Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,tissue specificity:Plasma.,
Protein name
Vitamin K-dependent protein Z
Other name
PROZ; Vitamin K-dependent protein Z
Human protein sequence Database
P22891
Mouse protein sequence database
Q9CQW3
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Plasma.
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