Immunogen
Purified recombinant fragment of PSA (aa26-251) expressed in E. Coli.
Specificity
PSA Monoclonal Antibody detects endogenous levels of PSA protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Preferential cleavage: -Tyr-|-Xaa-.,function:Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.,online information:Prostate-specific antigen entry,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,
Protein name
Prostate-specific antigen
Other name
KLK3; APS; Prostate-specific antigen; PSA; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
Fields
>>Pathways in cancer;>>Prostate cancer
Human protein sequence Database
P07288
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Leukocyte,PNS,Prostate,
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