Immunogen
Purified recombinant fragment of human WIF-1 expressed in E. Coli.
Specificity
WIF-1 Monoclonal Antibody detects endogenous levels of WIF-1 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010],
Function
function:Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.,similarity:Contains 1 WIF domain.,similarity:Contains 5 EGF-like domains.,
Protein name
Wnt inhibitory factor 1
Other name
WIF1; Wnt inhibitory factor 1; WIF-1
Fields
>>Wnt signaling pathway
Human protein sequence Database
Q9Y5W5
Mouse protein sequence database
Q9WUA1
Rat protein sequence database
Cellular localization
Secreted.
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