Immunogen
Purified recombinant human Hip protein fragments expressed in E.coli.
Specificity
Hip Monoclonal Antibody detects endogenous levels of Hip protein.
Formulation
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Dilution rate
Western Blot: 1/1000 - 1/2000. Immunohistochemistry: 1/500 - 1/1000. Immunofluorescence: 1/100 - 1/500. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013],
Function
function:One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.,similarity:Belongs to the FAM10 family.,similarity:Contains 1 STI1 domain.,similarity:Contains 3 TPR repeats.,subunit:Homotetramer. Interacts with HSC70 as well as DNAJ homologs and HSP90.,
Protein name
Hsc70-interacting protein
Other name
ST13; AAG2; FAM10A1; HIP; SNC6; Hsc70-interacting protein; Hip; Aging-associated protein 2; Progesterone receptor-associated p48 protein; Protein FAM10A1; Putative tumor suppressor ST13; Renal carcinoma antigen NY-REN-33; Suppression of tum
Human protein sequence Database
P50502
Mouse protein sequence database
Q99L47
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Colon mucosa,Epithelium,Fet
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