Molecular weight (DA)
76kD
Immunogen
Recombinant Protein of Gab1
Specificity
The antibody detects endogenous Gab1 protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function
function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,
Protein name
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Other name
GRB2-associated-binding protein 1 (GRB2-associated binder 1;Growth factor receptor bound protein 2-associated protein 1)
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Phospholipase D signaling pathway;>>Neurotrophin signaling pathway;>>Bacterial invasion of epithelial cells;>>Proteoglycans in cancer;>>Renal cell carcinoma;>>Hepatocellular carcinoma;>>Gastric cancer
Human protein sequence Database
Q13480
Mouse protein sequence database
Q9QYY0
Rat protein sequence database
Cellular localization
cytosol,
Tissue expression
Testis,Whole embryo,
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