Molecular weight (DA)
32kD
Immunogen
Synthesized phosho peptide around human MARCKS (Ser159 and 163)
Specificity
This antibody detects endogenous levels of Human Mouse Rat MARCKS (phospho-Ser159 or 163)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],
Function
function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,
Gene Name
MARCKS MACS PRKCSL
Protein name
MARCKS (Ser159/163)
Other name
Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (80K-L protein) (PKCSL)
Fields
>>Fc gamma R-mediated phagocytosis;>>MicroRNAs in cancer
Human protein sequence Database
P29966
Mouse protein sequence database
P26645
Rat protein sequence database
P30009
Cellular localization
Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .
Tissue expression
Blood,Brain,Epithelium,Muscle,Skin,
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