Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARRC. AA range:339-388
Specificity
Arrestin-C Polyclonal Antibody detects endogenous levels of Arrestin-C protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016],
Function
function:May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.,similarity:Belongs to the arrestin family.,tissue specificity:Inner and outer segments, and the inner plexiform regions of the retina.,
Other name
ARR3; ARRX; CAR; Arrestin-C; Cone arrestin; C-arrestin; cArr; Retinal cone arrestin-3; X-arrestin
Human protein sequence Database
P36575
Mouse protein sequence database
Q9EQP6
Rat protein sequence database
Cellular localization
Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment .
Tissue expression
Inner and outer segments, and the inner plexiform regions of the retina.
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