Molecular weight (DA)
62kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARSK. AA range:481-530
Specificity
Arylsulfatase K Polyclonal Antibody detects endogenous levels of Arylsulfatase K protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008],
Function
cofactor:Binds 1 calcium ion per subunit.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,
Protein name
Arylsulfatase K
Abbreviation
Arylsulfatase K
Other name
ARSK; TSULF; Arylsulfatase K; ASK; Telethon sulfatase
Human protein sequence Database
Q6UWY0
Mouse protein sequence database
Q9D2L1
Rat protein sequence database
Q32KJ2
Cellular localization
Secreted . Lysosome .
Tissue expression
Expressed at high levels in the placenta and pancreas (PubMed:23986440). Expressed at intermediate levels in the lung, brain, heart, liver and kidney and at low levels in the muscle (PubMed:23986440).
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