Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CHST2. AA range:1-50
Specificity
CHST2 Polyclonal Antibody detects endogenous levels of CHST2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This locus encodes a sulfotransferase protein. The encoded enzyme catalyzes the sulfation of a nonreducing N-acetylglucosamine residue, and may play a role in biosynthesis of 6-sulfosialyl Lewis X antigen. [provided by RefSeq, Aug 2011],
Function
caution:It is uncertain whether Met-1 or Met-48 is the initiator.,function:Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as L-selectin ligands. L-selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of L-selectin ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains.,induction:Up-regulated upon cytokine activation.,online information:GlycoGene database,similarity:Belongs to the sulfotransferase 1 family.
Protein name
Carbohydrate sulfotransferase 2
Other name
CHST2; GN6ST; Carbohydrate sulfotransferase 2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; GST-2; N-acetylglucosamine 6-O-sulfotransferase 1; GlcNAc6ST-1; Gn6ST-1
Fields
>>Glycosaminoglycan biosynthesis - keratan sulfate
Human protein sequence Database
Q9Y4C5
Mouse protein sequence database
Q80WV3
Rat protein sequence database
Cellular localization
Golgi apparatus, trans-Golgi network membrane ; Single-pass type II membrane protein .
Tissue expression
Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes.
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