Immunogen
The antiserum was produced against synthesized peptide derived from human Defensin alpha4. AA range:27-76
Specificity
Defensin α4 Polyclonal Antibody detects endogenous levels of Defensin α4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
defensin alpha 4(DEFA4) Homo sapiens Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014],
Function
function:Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with HIV-1 (in vitro). Inhibits corticotropin (ACTH)-stimulated corticosterone production.,similarity:Belongs to the alpha-defensin family.,subunit:Homodimer.,
Protein name
Neutrophil defensin 4
Other name
DEFA4; DEF4; Neutrophil defensin 4; Defensin; alpha 4; HNP-4; HP-4
Fields
>>NOD-like receptor signaling pathway;>>Staphylococcus aureus infection;>>Transcriptional misregulation in cancer
Human protein sequence Database
P12838
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted . Cytoplasmic vesicle, secretory vesicle . Stored as mature peptide in neutrophil granules. .
Tissue expression
Expressed in neutrophils (at protein level) (PubMed:2843187, PubMed:2500436, PubMed:2501794). Expressed in bone marrow (PubMed:8469233).
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