Molecular weight (DA)
68kD
Immunogen
The antiserum was produced against synthesized peptide derived from human EPN2. AA range:271-320
Specificity
Epsin 2 Polyclonal Antibody detects endogenous levels of Epsin 2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The DPW repeat domain is involved in AP-2 and clathrin binding.,domain:The NPF repeat domain is involved in EPS15 binding.,function:Plays a role in the formation of clathrin-coated invaginations and endocytosis.,PTM:Ubiquitinated.,similarity:Belongs to the epsin family.,similarity:Contains 1 ENTH (epsin N-terminal homology) domain.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,subcellular location:In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.,subunit:Binds EPS15 (By similarity). Binds AP-2 and clathrin.,tissue specificity:Highest expression is found in brain. Detected at lower levels in lung and liver.,
Other name
EPN2; KIAA1065; Epsin-2; EPS-15-interacting protein 2
Human protein sequence Database
O95208
Mouse protein sequence database
Q8CHU3
Rat protein sequence database
Q9Z1Z3
Cellular localization
Cytoplasm . Cytoplasmic vesicle, clathrin-coated vesicle . In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex.
Tissue expression
Highest expression is found in brain. Detected at lower levels in lung and liver.
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