Molecular weight (DA)
78kD
Immunogen
The antiserum was produced against synthesized peptide derived from human THOC5. AA range:561-610
Specificity
FMIP Polyclonal Antibody detects endogenous levels of FMIP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
function:May be involved in the differentiation of granulocytes and adipocytes.,PTM:Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the THOC5 family.,subcellular location:Shuttles between nucleus and cytoplasm.,subunit:Interacts with phosphorylated CSF1R.,tissue specificity:Ubiquitously expressed.,
Function
function:May be involved in the differentiation of granulocytes and adipocytes.,PTM:Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the THOC5 family.,subcellular location:Shuttles between nucleus and cytoplasm.,subunit:Interacts with phosphorylated CSF1R.,tissue specificity:Ubiquitously expressed.,
Protein name
THO complex subunit 5 homolog
Other name
THOC5; C22orf19; KIAA0983; THO complex subunit 5 homolog; Functional spliceosome-associated protein 79; fSAP79; NF2/meningioma region protein pK1.3; Placental protein 39.2; PP39.2; hTREX90
Fields
>>Nucleocytoplasmic transport
Human protein sequence Database
Q13769
Mouse protein sequence database
Q8BKT7
Rat protein sequence database
Q68FX7
Cellular localization
Nucleus . Cytoplasm . Shuttles between nucleus and cytoplasm. .
Tissue expression
Ubiquitously expressed.
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