Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CHST8. AA range:341-390
Specificity
GalNAc4ST-1 Polyclonal Antibody detects endogenous levels of GalNAc4ST-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011],
Function
caution:PubMed:10988300 reports the possible existence of a secreted isoform starting at Met-119. However, they do not provide any experimental evidence.,function:Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Only active against terminal GalNAcbeta1,GalNAcbeta. Not active toward chondroitin.,induction:Down-regulated (17-fold) in prion-infected cells.,similarity:Belongs to the sulfotransferase 2 family.,tissue specificity:Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary glan
Protein name
Carbohydrate sulfotransferase 8
Other name
CHST8; Carbohydrate sulfotransferase 8; GalNAc-4-O-sulfotransferase 1; GalNAc-4-ST1; GalNAc4ST-1; N-acetylgalactosamine-4-O-sulfotransferase 1
Fields
>>Various types of N-glycan biosynthesis;>>Metabolic pathways
Human protein sequence Database
Q9H2A9
Mouse protein sequence database
Q8BQ86
Rat protein sequence database
Cellular localization
Golgi apparatus membrane ; Single-pass type II membrane protein .
Tissue expression
Predominantly expressed in pituitary gland. In brain, it is expressed in pituitary gland, cerebellum, medulla oblongata, pons, thalamus and spinal cord. Expressed in the epidermis. Expressed at lower level in lung, spleen, adrenal gland, placenta, prostate, testis, mammary gland and trachea.
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