Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Guanylate Cyclase beta. AA range:10-59
Specificity
GCS-β-1 Polyclonal Antibody detects endogenous levels of GCS-β-1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
Function
catalytic activity:GTP = 3',5'-cyclic GMP + diphosphate.,cofactor:Binds 1 or 2 heme groups per heterodimer.,enzyme regulation:Activated by nitric oxide in the presence of magnesium or manganese ions.,miscellaneous:There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 1 guanylate cyclase domain.,subunit:Heterodimer of an alpha and a beta chain.,
Protein name
Guanylate cyclase soluble subunit beta-1
Other name
GUCY1B3; GUC1B3; GUCSB3; GUCY1B1; Guanylate cyclase soluble subunit beta-1; GCS-beta-1; Guanylate cyclase soluble subunit beta-3; GCS-beta-3; Soluble guanylate cyclase small subunit
Fields
>>Purine metabolism;>>Metabolic pathways;>>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Long-term depression;>>Oxytocin signaling pathway;>>Renin secretion;>>Salivary secretion
Human protein sequence Database
Q02153
Mouse protein sequence database
O54865
Rat protein sequence database
P20595
Cellular localization
Cytoplasm .
Tissue expression
Detected in brain cortex and cerebellum (at protein level).
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