Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GCS-beta-2. AA range:53-102
Specificity
GCS-β-2 Polyclonal Antibody detects endogenous levels of GCS-β-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide. Unlike other guanylyl cyclases, GUCY1B2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation.
Protein name
Guanylate cyclase soluble subunit beta-2
Other name
GUCY1B2; Guanylate cyclase soluble subunit beta-2; GCS-beta-2
Human protein sequence Database
O75343
Mouse protein sequence database
Rat protein sequence database
P22717
Cellular localization
Cytoplasm.
Tissue expression
Expressed in gastric signet ring cell carcinoma, but not in the normal stomach.
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