Molecular weight (DA)
31kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MARCKS. AA range:126-175
Specificity
MARCKS Polyclonal Antibody detects endogenous levels of MARCKS protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],
Function
function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,
Protein name
Myristoylated alanine-rich C-kinase substrate
Other name
MARCKS; MACS; PRKCSL; Myristoylated alanine-rich C-kinase substrate; MARCKS; Protein kinase C substrate; 80 kDa protein, light chain; 80K-L protein; PKCSL
Fields
>>Fc gamma R-mediated phagocytosis;>>MicroRNAs in cancer
Human protein sequence Database
P29966
Mouse protein sequence database
P26645
Rat protein sequence database
P30009
Cellular localization
Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .
Tissue expression
Blood,Brain,Epithelium,Muscle,Skin,
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