Molecular weight (DA)
43kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SERPINB7. AA range:111-160
Specificity
Megsin Polyclonal Antibody detects endogenous levels of Megsin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
Function
function:Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin.,similarity:Belongs to the serpin family.,similarity:Belongs to the serpin family. Ov-serpin subfamily.,tissue specificity:Predominantly expressed in mesangial cells.,
Other name
SERPINB7; Serpin B7; Megsin; TP55
Human protein sequence Database
O75635
Mouse protein sequence database
Q9D695
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Predominantly expressed in mesangial cells. Expressed in the epidermis of the whole body.
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