Molecular weight (DA)
15kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90
Specificity
Melan-A Polyclonal Antibody detects endogenous levels of Melan-A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
Function
tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,
Protein name
Melanoma antigen recognized by T-cells 1
Other name
MLANA; MART1; Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A
Human protein sequence Database
Q16655
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
Tissue expression
Expression is restricted to melanoma and melanocyte cell lines and retina.
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