Immunogen
The antiserum was produced against synthesized peptide derived from human MRPL52. AA range:71-120
Specificity
MRP-L52 Polyclonal Antibody detects endogenous levels of MRP-L52 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008],
Function
subunit:Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.,
Protein name
39S ribosomal protein L52 mitochondrial
Other name
MRPL52; 39S ribosomal protein L52; mitochondrial; L52mt; MRP-L52
Human protein sequence Database
Q86TS9
Mouse protein sequence database
Q9D0Y8
Rat protein sequence database
Cellular localization
Mitochondrion .
Tissue expression
Brain,Placenta,
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