Molecular weight (DA)
85kD
Immunogen
The antiserum was produced against synthesized peptide derived from human NOC2L. AA range:602-651
Specificity
NOC2L Polyclonal Antibody detects endogenous levels of NOC2L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
NOC2 like nucleolar associated transcriptional repressor(NOC2L) Homo sapiens Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008],
Function
similarity:Belongs to the NOC2 family.,
Protein name
Nucleolar complex protein 2 homolog
Other name
NOC2L; NIR; Nucleolar complex protein 2 homolog; Protein NOC2 homolog; NOC2-like protein; Novel INHAT repressor
Human protein sequence Database
Q9Y3T9
Mouse protein sequence database
Q9WV70
Rat protein sequence database
Cellular localization
Nucleus, nucleoplasm. Nucleus, nucleolus. Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D. Predominantly detected in the nucleoli in non-mitotic cells. Predominantly detected in nucleoplasma in cells undergoing mitosis.
Tissue expression
Brain,Epithelium,Placenta,
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