Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PABPC3. AA range:352-401
Specificity
PABP3 Polyclonal Antibody detects endogenous levels of PABP3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002],
Function
function:Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.,similarity:Belongs to the polyadenylate-binding protein type-1 family.,similarity:Contains 1 PABC domain.,similarity:Contains 4 RRM (RNA recognition motif) domains.,tissue specificity:Testis specific.,
Protein name
Polyadenylate-binding protein 3
Other name
PABPC3; PABP3; PABPL3; Polyadenylate-binding protein 3; PABP-3; Poly(A)-binding protein 3; Testis-specific poly(A)-binding protein
Fields
>>mRNA surveillance pathway;>>RNA degradation
Human protein sequence Database
Q9H361
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Testis specific.
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