Molecular weight (DA)
90kD
Immunogen
Synthesized peptide derived from the Internal region of human Plasminogen.
Specificity
Plasminogen Polyclonal Antibody detects endogenous levels of Plasminogen protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p: 100-300.WB: 1/500 - 1/2000. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009],
Function
catalytic activity:Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.,disease:Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis.,disease:Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed "ligneous" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract.,domain:Kringle domains mediate interaction with
Other name
PLG; Plasminogen
Fields
>>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades;>>Staphylococcus aureus infection;>>Influenza A
Human protein sequence Database
P00747
Mouse protein sequence database
P20918
Rat protein sequence database
Cellular localization
Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
Tissue expression
Present in plasma and many other extracellular fluids. It is synthesized in the liver.
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